For PC gamers, (the leading Xbox 360 emulator) has made huge strides. However, it cannot run raw, unpatched ISOs directly.
If you are running an RGH (Reset Glitch Hack) console, you don't want an ISO. You want a "Games on Demand" (GoD) format. This tool "patches" the ISO by converting it into a format the console can read directly from a hard drive. 3. Xbox 360 ISO Extract xbox 360 roms iso patched
For PC players, tools like the Xenia emulator can run standard ISOs, but the scene continues to release patches for translations, frame rate unlocks, and "XEX" file modifications that modernize the 360 experience. The Community Legacy Scene History - ConsoleMods Wiki For PC gamers, (the leading Xbox 360 emulator)