In simple terms, shaders are tiny programs that tell your GPU how to render light, shadows, and textures. On a Switch, these are pre-compiled. On Ryujinx, the emulator has to "translate" them for your PC hardware the first time they appear on screen. The Result:
A Vulkan cache built on an NVIDIA RTX 3080 will likely cause visual corruption or crashes if used on an AMD Radeon 6800 XT. ryujinx totk shader cache